Xiangyang Lou

Xiangyang Lou, Ph.D.

Research Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5933
Business Email: xlou@ufl.edu

About Xiangyang Lou

Dr. Lou is a Research Professor in the Department of Biostatistics, the University of Florida and an Adjunct Professor in the Department of Mathematics and Statistics, the University of Arkansas at Little Rock. Dr. Lou earned his Ph.D. in of Statistical Genetics and Bioinformatics from Zhejiang University, China, in 1997. And then he was recruited as an Assistant Professor at Zhejiang University. He came to the U.S. for pursuing postdoctoral training in the Department of Statistics, the University of Florida, in 2002. He was an Assistant Professor at the University of Virginia, an Associate Professor at the University of Alabama at Birmingham, Tulane University, and the University of Arkansas for Medical Sciences, and a Professor at the University of Arkansas for Medical Sciences.

Accomplishments

The 1st prize of Zhejiang Province’s Science and Technology Award in 2006
2006 · Zhejiang Province People’s Government

Teaching Profile

Courses Taught
2021-2024
PHC7979 Advanced Research
2023-2024
PHC6063 Biostatistical Consulting
2023-2024
PHC7980 Research for Doctoral Dissertation
2023
PHC6905 Independent Study

Research Profile

Dr. Lou’s research interests include biostatistics, bioinformatics, computational biology, statistical genomics, and study design and data management/innovation for clinical trials. Dr. Lou’s research primarily concentrates on developing and applying powerful innovative analysis methods to solve real-world biological problems in biomedical sciences and other sciences such as detecting multifactor interactions and translating data from disparate and fragmented sources into a holistic biological picture. Specifically, the methodological research includes to develop new machine learning and hidden Markov model-based analytical methods for feature selection and data integration.

Areas of Interest
  • Clinical Trials Design & Analysis
  • Big data analytics
  • Bioinformatics
  • Biostatistics
  • Computational biology
  • Statistical methods
Open Researcher and Contributor ID (ORCID)

0000-0002-8305-827X

Publications

2024
Contaminant Organism Growth in Febrile Infants at Low Risk for Invasive Bacterial Infection.
The Journal of pediatrics. 267 [DOI] 10.1016/j.jpeds.2024.113910. [PMID] 38218368.
2024
Gene-based association tests in family samples using GWAS summary statistics.
Genetic epidemiology. [DOI] 10.1002/gepi.22548. [PMID] 38317324.
2024
Perspectives of the Friedreich ataxia community on gene therapy clinical trials.
Molecular therapy. Methods & clinical development. 32(1) [DOI] 10.1016/j.omtm.2023.101179. [PMID] 38261944.
2024
Race, Ethnicity, Language, and the Treatment of Low-Risk Febrile Infants.
JAMA pediatrics. 178(1):55-64 [DOI] 10.1001/jamapediatrics.2023.4890. [PMID] 37955907.
2023
Continuity corrected Wilson interval for the difference of two independent proportions.
Journal of statistical theory and applications : JSTA. 22(1-2):38-53 [DOI] 10.1007/s44199-023-00054-8. [PMID] 37982044.
2023
Development and Validation of a Mixed-Reality Simulator for Reducing Biopsy Core Deviation During Simulated Freehand Systematic Prostate Biopsy.
Simulation in healthcare : journal of the Society for Simulation in Healthcare. [DOI] 10.1097/SIH.0000000000000723. [PMID] 36976805.
2023
Impact of Institutional Universal Microsatellite-Instability (MSI) Reflex Testing on Molecular Profiling Differences Between Younger and Older Patients with Colorectal Cancer.
Clinical colorectal cancer. 22(1):153-159 [DOI] 10.1016/j.clcc.2022.09.004. [PMID] 36319582.
2023
MOVER-R and Penalized MOVER-R Confidence Intervals for the Ratio of Two Quantities.
The American statistician. 77(4):381-389 [DOI] 10.1080/00031305.2023.2173294. [PMID] 38188694.
2023
Pre-Enrollment Steps and Run-Ins in Weight Loss Trials: A Meta-Regression
American Journal of Preventive Medicine. 64(6):910-917 [DOI] 10.1016/j.amepre.2023.01.034.
2023
Privacy Concerns in Group Format Lifestyle Interventions for Obesity
International Journal of Behavioral Medicine. 30(5):693-704 [DOI] 10.1007/s12529-022-10134-1.
2023
Racial and Ethnic Differences in Initiation of Menthol Tobacco Smoking and Subsequent Tobacco Use in the Population Assessment of Tobacco and Health Study, Waves 1–4 (2013–2018)
Nicotine and Tobacco Research. 25(8):1440-1446 [DOI] 10.1093/ntr/ntad055.
2022
A genome-wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study.
American journal of medical genetics. Part A. 188(8):2303-2314 [DOI] 10.1002/ajmg.a.62759. [PMID] 35451555.
2022
Disparities and implicit bias in the management of low-risk febrile infants: a mixed methods study protocol.
BMJ open. 12(9) [DOI] 10.1136/bmjopen-2022-063611. [PMID] 36127098.
2022
Dissecting Complex Traits Using Omics Data: A Review on the Linear Mixed Models and Their Application in GWAS.
Plants (Basel, Switzerland). 11(23) [DOI] 10.3390/plants11233277. [PMID] 36501317.
2022
Genome-wide association studies revealed complex genetic architecture and breeding perspective of maize ear traits.
BMC plant biology. 22(1) [DOI] 10.1186/s12870-022-03913-1. [PMID] 36397013.
2022
The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma
Neoplasia. 28 [DOI] 10.1016/j.neo.2022.100789. [PMID] 35395492.
2022
Transition to smoking cessation among dual cigarette and e-cigarette users in the population assessment of tobacco and health study, Waves 3 and 4 (2015-2017).
Addictive behaviors. 129 [DOI] 10.1016/j.addbeh.2022.107284. [PMID] 35217415.
2021
Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family‐based hybrid designs
Genetic Epidemiology. 45(2):171-189 [DOI] 10.1002/gepi.22363. [PMID] 32996630.
2020
Brain Cortical Structure and Executive Function in Children May Be Influenced by Parental Choices of Infant Diets
American Journal of Neuroradiology. 41(7):1302-1308 [DOI] 10.3174/ajnr.a6601.
2020
Conditional and unconditional genome-wide association study reveal complicate genetic architecture of human body weight and impacts of smoking.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-68935-x. [PMID] 32699216.
2019
Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes.
Radiology. 292(1):179-187 [DOI] 10.1148/radiol.2019182564. [PMID] 31161971.
2019
Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data.
Birth defects research. 111(20):1618-1632 [DOI] 10.1002/bdr2.1554. [PMID] 31328417.
2019
Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits
Genetic Epidemiology. 43(1):24-36 [DOI] 10.1002/gepi.22169. [PMID] 30387901.
2018
Dissection of complicate genetic architecture and breeding perspective of cottonseed traits by genome-wide association study.
BMC genomics. 19(1) [DOI] 10.1186/s12864-018-4837-0. [PMID] 29895260.
2017
Genetic dissection of yield traits in super hybrid rice Xieyou9308 using both unconditional and conditional genome-wide association mapping.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-00938-7. [PMID] 28400567.
2016
Dissection of genetic architecture of rice plant height and heading date by multiple-strategy-based association studies.
Scientific reports. 6 [DOI] 10.1038/srep29718. [PMID] 27406081.
2016
GMDR: Versatile Software for Detecting Gene-Gene and Gene-Environ- ment Interactions Underlying Complex Traits.
Current genomics. 17(5):396-402 [DOI] 10.2174/1389202917666160513102612. [PMID] 28479868.
2015
A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model.
Human heredity. 79(2):60-8 [DOI] 10.1159/000375409. [PMID] 25791389.
2015
Associating Multivariate Quantitative Phenotypes with Genetic Variants in Family Samples with a Novel Kernel Machine Regression Method.
Genetics. 201(4):1329-39 [DOI] 10.1534/genetics.115.178590. [PMID] 26482791.
2015
Detection of Epistatic and Gene-Environment Interactions Underlying Three Quality Traits in Rice Using High-Throughput Genome-Wide Data.
BioMed research international. 2015 [DOI] 10.1155/2015/135782. [PMID] 26345334.
2015
Dissecting genetic architecture underlying seed traits in multiple environments.
Genetics. 199(1):61-71 [DOI] 10.1534/genetics.114.168203. [PMID] 25335503.
2015
Rare-Variant Kernel Machine Test for Longitudinal Data from Population and Family Samples.
Human heredity. 80(3):126-38 [DOI] 10.1159/000445057. [PMID] 27161037.
2015
Statistical Analysis of High-Dimensional Genetic Data in Complex Traits
BioMed Research International. 2015:1-2 [DOI] 10.1155/2015/564273. [PMID] 26346557.
2015
Transcriptome analysis of Brassica napus pod using RNA-Seq and identification of lipid-related candidate genes.
BMC genomics. 16 [DOI] 10.1186/s12864-015-2062-7. [PMID] 26499887.
2014
A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence.
Human genetics. 133(2):139-50 [DOI] 10.1007/s00439-013-1361-9. [PMID] 24057800.
2014
Kernel-machine testing coupled with a rank-truncation method for genetic pathway analysis.
Genetic epidemiology. 38(5):447-56 [DOI] 10.1002/gepi.21813. [PMID] 24849109.
2014
Multivariate dimensionality reduction approaches to identify gene-gene and gene-environment interactions underlying multiple complex traits.
PloS one. 9(9) [DOI] 10.1371/journal.pone.0108103. [PMID] 25259584.
2014
Rare variant association testing by adaptive combination of P-values.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0085728. [PMID] 24454922.
2013
Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.
Genetic epidemiology. 37(6):560-70 [DOI] 10.1002/gepi.21740. [PMID] 23740760.
2012
On epistasis: a methodological review for detecting gene-gene interactions underlying various types of phenotypic traits.
Recent patents on biotechnology. 6(3):230-6 [PMID] 23003010.
2011
A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions.
Statistics and its interface. 4(3):295-304 [PMID] 21927640.
2011
A new mapping method for quantitative trait loci of silkworm.
BMC genetics. 12 [DOI] 10.1186/1471-2156-12-19. [PMID] 21276233.
2011
Practical and theoretical considerations in study design for detecting gene-gene interactions using MDR and GMDR approaches.
PloS one. 6(2) [DOI] 10.1371/journal.pone.0016981. [PMID] 21386969.
2009
An optimal DNA pooling strategy for progressive fine mapping.
Genetica. 135(3):267-81 [DOI] 10.1007/s10709-008-9275-5. [PMID] 18506582.
2009
Efficient mapping of a female sterile gene in wheat (Triticum aestivum L.).
Genetics research. 91(5):337-43 [DOI] 10.1017/S0016672309990218. [PMID] 19922697.
2008
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.
American journal of human genetics. 83(4):457-67 [DOI] 10.1016/j.ajhg.2008.09.001. [PMID] 18834969.
2008
Analysis of genetic effects of nuclear-cytoplasmic interaction on quantitative traits: genetic models for seed traits of plants.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 116(6):769-76 [DOI] 10.1007/s00122-008-0709-3. [PMID] 18283427.
2007
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
American journal of human genetics. 80(6):1125-37 [PMID] 17503330.
2007
Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans.
Human molecular genetics. 16(2):142-53 [PMID] 17164261.
2006
Estimating effects of a single gene and polygenes on quantitative traits from a diallel design.
Genetica. 128(1-3):471-84 [PMID] 17028974.
2006
Improvement of mapping accuracy by unifying linkage and association analysis.
Genetics. 172(1):647-61 [PMID] 16172505.
2005
Genetic control of the opaque-2 gene and background polygenes over some kernel traits in maize (Zea mays L.).
Genetica. 124(2-3):291-300 [PMID] 16134340.
2003
A general statistical framework for mapping quantitative trait loci in nonmodel systems: issue for characterizing linkage phases.
Genetics. 165(2):901-13 [PMID] 14573497.
2003
A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis.
Genetics. 163(4):1533-48 [PMID] 12702696.
2003
A method for marker-assisted selection based on QTLs with epistatic effects.
Genetica. 119(1):75-86 [PMID] 12903749.
2003
The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree.
Mammalian genome : official journal of the International Mammalian Genome Society. 14(8):555-64 [PMID] 12925888.

Grants

Sep 2023 ACTIVE
Increasing initiation of evidence-based weight loss treatment
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2023 ACTIVE
Implicit racial bias in pediatric emergency medicine: A foundational investigation of physician behaviors
Role: Other
Funding: NATL INST OF HLTH NIMHD
Jul 2023 ACTIVE
Advancing Precision Lung Cancer Surveillance and Outcomes in Diverse Populations (PLuS2)
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jun 2023 ACTIVE
Innovative Deep Phenotyping of African Americans at Risk for Alzheimers disease
Role: Co-Investigator
Funding: UNIV OF MIAMI via NATL INST OF HLTH NIA
May 2023 ACTIVE
Cognitively engaging walking exercise and neuromodulation to enhance brain function in older adults
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2022 – Sep 2023
Precision Clinical Trial Recruitment to Promote Cancer Health Equity Across Florida
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Sep 2022 ACTIVE
Progressive resistance exercise and dystonia pathophysiology.
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2022 ACTIVE
Functional Decline in Low Functioning Older Adults; Role of iron dysregulation
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2022 ACTIVE
UF HEALTH CANCER CENTER PILOT PROJECTS GRANTS FUNDED THROUGHTHE FLORIDA CONSORTIUM OF NATIONAL CANCER INSTITUTE CENTER
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2022 ACTIVE
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
Role: Co-Investigator
Funding: NATL INST OF HLTH NIMH
Sep 2021 ACTIVE
Tailoring Recruitment Communication using Virtual Human Technology to Increase Participation of Older Minority Adults in Clinical Trials
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2021 ACTIVE
Southern HIV and Alcohol Research Consortium Biomedical Data Repository
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
Aug 2021 ACTIVE
Preclinical Markers of Parkinsonism
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
May 2021 ACTIVE
Immunomodulation Approaches to Improve Safety And Efficacy of Gene Therapy Treatment in Friedreichs Ataxia
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2020 ACTIVE
Phentermine/tOpiramate to end Obesity and Uric acid stones Trial (POuND OUT)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2019 ACTIVE
A telescopic algorithm for two-dimensional hidden Markov models with application to genetic studies
Role: Principal Investigator
Funding: NATL SCIENCE FOU

Education

Post doctorate
2005 · University of Texas Health Science Center at San Antonio
Post doctorate
2004 · University of Florida
Ph.D.
1997 · Zhejiang University, China
Master
1994 · Zhejiang University, China
Associate
1985 · Zhejiang University, China

Contact Details

Phones:
Business:
(352) 294-5933
Emails:
Business:
xlou@ufl.edu
Addresses:
Business Mailing:
PO BOX 117450
GAINESVILLE FL 326110001
Business Street:
2004 MOWRY ROAD, CTRB 5TH FLR.
GAINESVILLE FL 326107450