Dr. McCrae’s program of sleep research focuses on the mechanisms underlying normal and pathological sleep, the link between sleep and cognition, and the efficacy and effectiveness of cognitive-behavioral interventions to treat insomnia in older individuals, dementia caregivers, and medical populations (pain, cardiac disease, cancer, and end stage renal disease). Her research involves the application of novel statistical approaches for evaluating intraindividual variability in treatment outcomes in longitudinal, cognitive-behavioral protocols as well as the use of neuroimaging to study the impact of cognitive-behavioral treatment protocols for insomnia and pain on brain structure and function.